Conclusions: Anaphylactic shock extends the living period of guinea pigs during experimental anthrax by 2-3 times in comparison with the control. During the administration of Second Tsenkovskiy Vaccine soon after the disappearance of shock symptons, the period of survival of the test animals was increased by three times. When the Second Tsenkovskiy Vaccine was administered after 2-3 days following shock, the period of survival of the test animals was increased by two times.